Cisplatin induced cardiotoxicity

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WebFeb 2, 2024 · 5.1 Cisplatin-Induced Nephrotoxicity. Cisplatin, a potent chemotherapeutic agent used for treating various types of solid organ tumors, is limited by its serious side effects in clinical application (Yu et al., 2024; Deng et al., 2024). Cisplatin can cause an increase in the expression of NF-κB and TNF-α in the liver and kidney (Park et al., 2024

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WebCardioprotective effect of zingerone against oxidative stress, inflammation, and apoptosis induced by cisplatin or gamma radiation in rats Despite their clinical benefits in cancer treatment, the deleterious effects on heart following chemo/radiotherapy are of increasing importance. WebAug 31, 2024 · However, the mechanism of CDDP-induced cardiotoxicity is poorly understood. Acetyl-l-carnitine (ALCAR) is an antioxidant agent with protective effects against the side effects of various chemotherapeutics. CDDP-induced cardiotoxicity and the protective role of ALCAR were evaluated in this study. port raymondmouth

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WebThe current study aimed to investigate the curative role of semaglutide's against cisplatin- induced cardiotoxicity and its relation to mitochondrial functions, dynamics, biogenesis, apoptosis, and redox status pathways. The study included 30 male rats divided into three groups: control, cisplatin-induced cardiotoxicity, and cisplatin-induced ... WebSep 1, 2024 · Cisplatin-induced cardiotoxicity severely limits its clinical application as an antitumor drug and increases the risk of cardiovascular disease. Icariin (ICA), the main … WebMar 21, 2024 · Cisplatin (CP) kills tumour cells by inducing senescence or triggering innate apoptotic pathways that cause irreparable DNA damage, and it is the most commonly used first-line drug for cancer treatment. 1 However, its clinical use is often limited by dose-related cardiotoxicity, 2 which includes arrhythmias, 3 angina pectoris, 4 and cardiac … port ratt trading profit

Recombinant human erythropoietin prevents cisplatin-induced ...

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WebJul 27, 2016 · Take for example the side effects of anticancer treatments: just a few years ago, side effects such as cardiotoxicity and myelotoxicity often forced the interruption of life-saving treatments. ... Callejo and colleagues examined in depth the state of art of cisplatin-induced ototoxicity. In addition to peripheral neurotoxicity, cisplatin ... WebSecondary prevention of anthracycline-induced cardiotoxicity has also gathered quite some scientific interest. Beta-blockers, aldosterone antagonists, angiotensin receptor blockers, angiotensin converting enzyme inhibitors, neurohormonal blocking drugs and implantable devices have and may still all be used. iron ore shipping companiesWebCardiotoxicity has been well documented as a side effect of cisplatin (CDDP) treatment. The inflammatory response plays a crucial role in the pathological process of CDDP … port rashid cruise terminal adresse

"WebIt may be induced by factors including direct toxicity, ion imbalance, heart infiltration and, in the case of neuroendocrine tumors, the influence of tumor excretions. Keywords: … " - Cisplatin induced cardiotoxicity

Cisplatin induced cardiotoxicity

WebApr 7, 2024 · This present study investigated the protective effects of asperuloside (ASP) against cadmium-induced nephrocardiac toxicity. Rats were treated with 50 mg/kg of ASP for five weeks and CdCl 2 (5 mg ... WebRats treated with rhEPO, simultaneously, before, or after Cisp injection, remarkably decreased DNA damage, highlighting an interesting cytoprotective strategy usingrhEPO against Cisp-induced liver and heart injuries. Cisplatin (Cisp) is one of the most effective chemotherapeutic agents. However, at higher doses, liver and heart injuries may occur. …

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WebAfter right heart catheterization, pathological results of a myocardial biopsy from the ventricular septum indicated no cardiac muscle hypertrophy, cardiac fibrosis, inflammatory cell infiltration, or myocyte disarray. Eventually, she was diagnosed as having pemetrexed-induced cardiomyopathy. WebJan 10, 2011 · Abstract. Increased oxidative stress and apoptosis have been implicated in the cardiotoxicity that limits the clinical use of cisplatin as an anti-tumoral drug. Our study …

WebIn Cisplatin group, cardiac muscle fibers appeared disorganized, disrupted or degenerated with pyknotic nuclei and showed a significant rise in the number of anti-P53 positive nuclei. Significant increments in the percent area of collagenous fibers and TNF-α immune-expression were observed. WebMay 9, 2024 · Busulfan-induced pulmonary injury; Cardiotoxicity of cancer chemotherapy agents other than anthracyclines, HER2-targeted agents, and fluoropyrimidines ... et al. …

WebQuercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway Authors Shih-Hao Wang 1 2 , Kun-Ling Tsai 3 4 , Wan-Ching Chou 3 , Hui-Ching Cheng 3 , Yu-Ting Huang 3 , Hsiu-Chung Ou 5 , Yun-Ching Chang 6 Affiliations WebOct 1, 2010 · The increase in MDA may be due to the formation of oxygen-free radicals during cisplatin-induced cardiotoxicity, which react with membrane lipids, proteins, and nucleic acids and can cause ...

WebApr 14, 2024 · While the exact mechanisms underlying the relationship between gut microbiota and chemotherapy-induced cardiotoxicity are not yet fully understood, …

WebJun 1, 2013 · There is evidence that oxidative stress is an important cause of cardiotoxicity by cancer chemotherapy including cisplatin in humans (Demkow et al., 2011, El-Awady et al., 2011, Hussein et al., 2012). The oxidative stress represents an imbalance between excessive generation and/or impaired removal of reactive oxygen species (ROS). iron ore sinter btpWebCisplatin-induced cardiotoxicity is rare, and the prevalence remains unknown. Jakubowski and Kemeny showed that cardiotoxicity occurs in 6% of the patients … iron ore siding picturesWebLung cancer is a malignant tumor characterized by a rapid proliferation rate, less survivability, high mortality, and metastatic potential. This review focuses on updated research about the clinical application of traditional Chinese medicine (TCM) as an adjuvant therapy to lung cancer treatment and the mechanisms of TCM effect on lung cancer in … port reader softwareWebCancer therapy can result in cardiac toxicity, such as cardiomyopathy. Cardiotoxicity with chemotherapeutic agents in the form of cardiomyopathy was first described in 1966 in patients receiving anthracyclines. 1 However, cancer treatment–induced arrhythmia (CTIA) has not attracted specific attention until recently. 2. port ratedWebDec 30, 2015 · El-Awady el-SE, Moustafa YM, Abo-Elmatty DM, Radwan A. Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. Eur Eur J … iron ore shipwreckWebFeb 6, 2024 · Abstract. The cardiotoxicity of chemotherapeutic drugs as cisplatin has become a major issue in recent years. The present study investigates the efficacy of … port rashid dubai hotelWebSep 15, 2024 · Cisplatin's side effects primarily include nephrotoxicity, gastrointestinal toxicity, neurotoxicity and ototoxicity. Cardiotoxicity is generally not defined as a side effect of cisplatin. However, over the past decade there has been a surge in the amount of clinical cases reporting a vast array of cardio-toxic events occurring during or shortly ... port rdp 3389 what is it used for